Sildenafil and Tadalafil are two drugs commonly used to treat erectile dysfunction or pulmonary hypertension At first glance, Sildenafil and Tadalafil have a great deal in common, but there are significant differences between the two.
Sildenafil is the generic form of the drug most commonly marketed as Viagra. It works by suppressing the action of the enzyme phosphodiesterase type-5, which in turn relaxes blood vessels. When Sildenafil is used to treat erectile dysfunction.
The improved blood flow to the penis enables the user to get and maintain an erection more easily, the same action of relaxing blood vessels to the heart is how it treats pulmonary hypertension.
Like Sildenafil, Tadalafil is the generic form of a commonly available drug, namely Cialis (it is also sold as Adcirca when used to treat pulmonary hypertension). Its action is similar, as it is also a PDE type-5 inhibitor, but the range of treatment is wider. Tadalafil is also used to treat the symptoms of a benign enlarged prostate.
Despite the similarities in how the drugs work, there are pronounced differences in their side effects and efficacies, and also the length of time taken before the effect becomes pronounced.
With Sildenafil, most users report a reaction to the drug within 30 minutes of ingestion. Tadalafil takes on average longer to work, with most users reporting effects within 45 minutes. The strength of the effect is roughly the same, with studies reporting increased satisfaction in users of both drugs.
The largest point of difference is in the duration of effect. Sildenafil typically remains in the blood stream for no more than 6 hours, whereas the effects of Tadalafil can last for anything from 18-36 hours. Whilst this makes it easier to initiate sexual encounters over a longer time frame, it’s worth bearing in mind if you are using any other medication at the same time.
Further differences can be found in the side effects. All users of PDE-5 inhibitors run the risk of upset stomach, headaches and blocked noses, due to the widening of blood vessels all over the body. Prolonged erection (Priapism) is a small risk with both drugs, but the number of reported cases is as yet too small to draw any accurate conclusion, as it has yet to be effectively studied.
Some Sildenafil users have reported blurred vision and flushing, there have also been incidences of Sildenafil use being linked to strokes, but this is again a statistically tiny incidence. Other side effects of Tadalafil include back pain and muscular pain occurring from 12-24 hours after use. Given Tadalafil’s longer duration in the bloodstream, the side effects engendered will be present longer.